Amanda Randles

Associate Professor at Duke & Creator of HARVEY Supercomputer Blood Simulator

Lifespan 1983–

Technical Depth advanced

Key Breakthrough HARVEY Massively Parallel Cardiovascular Hemodynamics Simulator (2016)

Focus Areas

supercomputing computational medicine fluid dynamics

Topic Keywords

#supercomputing #biomedical-hpc #fluid-dynamics #exascale #acm-hopper-award

Source: Historical Biographical Archive / Wikimedia Commons

Amanda Randles

Associate Professor at Duke & Creator of HARVEY Supercomputer Blood Simulator

Biographical Overview

Biomedical computer scientist and Alfred Winborne and Victoria Stover Mordecai Associate Professor at Duke University. Randles created HARVEY, a massively parallel fluid dynamics code executing across leadership-class supercomputers to simulate full human blood flow across hundreds of billions of cells.

"By simulating every single red blood cell flowing through the arterial tree, we turn the supercomputer into a non-invasive diagnostic microscope."
— Amanda Randles

Lifespan 1983–

Technical Depth advanced

Key Breakthrough HARVEY Massively Parallel Cardiovascular Hemodynamics Simulator (2016)

Focus Areas

supercomputing computational medicine fluid dynamics

Topic Keywords

#supercomputing #biomedical-hpc #fluid-dynamics #exascale #acm-hopper-award

Source: Historical Biographical Archive / Wikimedia Commons

💡

Historical Context & Impact

In short

While working at IBM Watson on the Blue Gene supercomputer, Randles asked whether physics algorithms could model the entire human circulatory system down to single red blood cells. Her HARVEY simulator runs across 1.6 million computing cores, simulating over 500 billion fluid particles flowing through real patient arteries.

Key Technical Breakthroughs & Inventions

HARVEY Massively Parallel Hemodynamics Code Developed HARVEY, a lattice Boltzmann code scaling to millions of GPU and CPU cores, modeling 3D cardiovascular blood flow at cellular resolution.

Simulation of Circulating Cancer Tumor Cells Simulated the fluid trajectories of circulating tumor cells (CTCs) through complex vascular networks to predict where metastatic cancer lodges.

Non-Invasive Virtual Fractional Flow Reserve (vFFR) Developed non-invasive supercomputer simulations of coronary arterial flow, reducing the need for invasive diagnostic heart catheterizations.

IBM Blue Gene/Q High-Performance Physics Engineered supercomputing communication primitives and molecular dynamics simulations at IBM Watson on the Blue Gene/Q architecture.